I've worked in trade book and museum book publishing for more than thirty years. I ran a publishing company that was nominated for a Carey Thomas Award for excellence in publishing. I've published somewhere around twenty books of my own as author, translator, or credited editor. I've been associated with several national best sellers. I've also worked in the magazine world. See my bio and list of publications for more.
You can't. Publishing is a tough game. It's also a slow one, so why waste time spinning your wheels? All you can do is play the odds to improve your chances.
No. There are plenty of examples of great writers and great books that had difficulty getting published. Publishing is a business. Marketability is the key.